Monday 3 March 2014

IVF - Frequently Asked Questions - Male & Female Fertility Treatment in India

1. Are there any restrictions on physical or personal activities during an IVF cycle?
  • Smoking: Stop smoking before ovulation induction begins. It is best to discontinue tobacco at least 3 months prior to an IVF cycle. If you cannot stop “cold turkey”, seek the care of your primary care physician. By products of tobacco have been demonstrated to be toxic to the oocyte (egg). We strongly recommend that all women, especially those undergoing fertility treatment, cease smoking.
  • Drinking: Alcohol is a drug, and should be avoided during infertility treatment and pregnancy. Please do not drink alcohol from the time fertility medications are initiated until the pregnancy test.
  • Medications: If you are taking any medication, prescription or over-the-counter, please inform your physician. Some medications may interfere with the fertility medications prescribed, some are not safe to use before an operation or medical procedure, and others might interfere with ovulation or pregnancy implantation.
  • An IVF cycle can be an emotional and stressful time for you and your partner. It may be helpful to have supportive personnel to speak to, such as friends and family, a clergy member, or a psychologist/therapist.
  • Heavy exercise such as aerobics, jogging, weight lifting etc. are prohibited during ovarian stimulation and until the pregnancy test results are known.
  • Acupuncture is permitted prior, during and after your IVF cycle but herbal supplements are absolutely prohibited.
2. Is the egg retrieval painful?
We do our egg retrievals under anesthesia you will be asleep for the procedure. Our anesthesia specialists use medications which heavily sedate you. You will be "asleep" however; you will not require a breathing tube. The beauty of this approach is that you will feel absolutely nothing, remember absolutely nothing, and will have few of or none of the typical side effects of anesthesia such as nausea and vomiting.

3. Will the egg retrieval damage my ovaries?
The data we have available tells us that it does not. There have been many women who have undergone multiple egg retrievals. The fact that they have responded to stimulation on subsequent occasions and gotten eggs and pregnancies on these occasions implies that the ovaries are OK after egg retrieval. There have been some limited studies looking at the appearance of the ovaries in women who have had egg retrievals and subsequent laparoscopic surgery. In those patients, the findings were normal.


From the point of your initial consultation , you may potentially start an IVF cycle within weeks. Your physician will determine the appropriate time frame for your fertility treatment.

IVF treatment into phases:

Phase One involves your initial consult and diagnostic evaluation. This can take days, but usually takes weeks or even a couple of months (depending on your menstrual cycle, logistical and financial details such as your travel schedule, availability, insurance requirements, etc.)

Phase Two is your cycle planning stage, which is heavy on logistical details such as obtaining IVF medications and learning how to mix and administer them. There is also blood work to be done, consent forms to be signed, payment to be made as well as other details to attend to during this phase.

Phase Two can last days, weeks or months, depending on your schedule, insurance, and availability.

Phase Three is the start of the cycle and usually lasts about two weeks. During this time you will be taking injectable medications and return  every couple of days for monitoring.

Phase Four is egg retrieval and embryo transfer. There are three to five days between the time when eggs are retrieved and embryos are put back into the uterus.

Phase Five is a pregnancy test and beyond.

5. If I am not pregnant, when can we try again?
Usually we ask that patients wait one or two complete menstrual cycles before beginning another ART cycle. Sometimes tests are required that may delay subsequent cycles.

We find that most couples will get pregnant within 2 tries. Occasionally, there may be a reason to do a third attempt but that is not common. More than this would really require extenuating circumstances such as a miscarriage due to a non-recurring reason, for example.

7. Is there a higher miscarriage rate for ART patients?
The miscarriage rate is about the same for ART as the general population. Many times older females undergo ART and their miscarriage rates are naturally higher. Since pregnancy testing is done two weeks after embryo transfer, we often know about spontaneous miscarriages in the very early stages of pregnancy. These miscarriages would probably go unnoticed in the general population.

8. What are my choices if my tubes have been tied?
Basically there are two choices, surgery to try and repair the tubes or IVF. There are pros and cons to each choice and often the best choice depends on your unique situation. Surgery offers the option of attempting pregnancy naturally indefinitely without repeated treatments, but carries the rare risks of surgery and in some cases is not successful depending on the type of tubal ligation or tubal damage done initially. IVF offers the chance for pregnancy without having to undergo an operation and maintaining contraception or birth control against future pregnancies after completion of your family.

9. How do we decide how many embryos to transfer?
Your physician will discuss this with you at the time of consent signing, but we usually follow the recommendations of The American Society for Reproductive Medicine guidelines:
  • Under 34 years old = 1-2 embryos
  • 35-37 years of age = 2-3 embryos
  • 38-40 years of age = 3 embryos
These numbers may vary depending on individual diagnosis and clinical circumstance.


10.How much does IVF cost?
The cost of IVF depends on the treatment and options selected. For IVF pricing information, click
here.

Friday 31 January 2014

Treatment for Low Sperm Count - ICSI (Intracytoplasmic Sperm Injection)

If there is a question of the sperm's ability to fertilize the egg, due to either a low sperm count or poor quality of the sperm, that poses no problem whatsoever. Intra-CytoplasmicSperm Injection (ICSI) would be performed instead of regular In Vitro Fertilization (IVF). With ICSI, the eggs are retrieved the same as if you were doing conventional IVF. However, the eggs and the sperm are then fertilized in the laboratory, by direct injection of a single sperm into each egg. Three days later the resulting embryos are simply placed into your uterus with no surgery, just as with IVF. Extra embryos are frozen for later attempts at pregnancy.
The availability of this Intra-Cytoplasmic Sperm Injection, "ICSI" technique (which was developed and perfected by the Brussels University and our institution in St. Louis) means that men whose sperm previously were too weak or too few to fertilize in vitro (IVF), now have no problem fertilizing their wife's eggs. The fertilization rate per egg using ICSI is about 70% despite the sperm being terrible, the fertilization rate per infertile couple is over 99% if the wife has adequate eggs, and the pregnancy rate per treatment cycle is over 50%. This is not significantly different from regular IVF with normal sperm. This technique is very cost-effective, and will give you the same high chance for getting pregnant as any couple with normal sperm.
Non-moving "dead" appearing sperm and inject it into a woman's egg, getting a normal embryo and a completely normal baby. So far, over 10,000 babies have been born with this new technique from men who were otherwise considered hopelessly sterile. The babies are physically, mentally, and genetically completely normal, no matter how poor or miserable the sperm of the father.
We can take a man who would otherwise have to resort to donor sperm, and if we can find just a few weak sperm in his otherwise sterile appearing ejaculate, it is more than enough to microsurgically inject these few sperm into his wife's eggs, fertilize them normally, and get her pregnant.
If there is absolutely no sperm in the ejaculate, we can perform a testicle biopsy, remove the few non-moving sperm that we find through a highly refined ultra micropipette, inject it into the wife's egg and still get her pregnant. Even in testicles where allegedly there is no sperm production, we can usually (but not always) find a few sperm, which is enough for successful ICSI.
About 70 percent of eggs get fertilized. Fertilization is confirmed 18-24 hours after retrieval. ICSI is a highly successful technique used to help couples who have previously failed to achieve conception with standard IVF.
Why is ICSI Done?
  • Very Low Sperm Count
  • Abnormally Shaped Sperm
  • Poor Sperm Movement
If a man does not have any sperm in his ejaculate, but he is producing sperm, they may be retrieved through testicular sperm extraction, or TESE. Sperm retrieved through TESE require the use of ICSI. ICSI is also used in cases of retrograde ejaculation, if the sperm are retrieved from the man’s urine




IVF India has complete range of services to handle any kind of infertility with the best of professionals to back the best in class technology at work.
  • In Vitro Fertilization (IVF)
  • Intra Uterine Insemination (IUI)
  • Intra Cytoplasmic Sperm Injection (ICSI)
  • Blastocyst Culture
  • Sperm Aspiration) PESA (Percutaneous Epididymal Sperm Aspiration)
  • Advanced Treatment Options like TESE (Testicular Sperm Extraction) MESA (Microsurgical Epididymal )
  • Cryopreservation
  • Laser Assisted Hatching
  • Embryo Transfer
  • Ovulation Induction
  • Egg Donation/Egg Sharing
  • Zona free Embryo Transfer
  • Semen Bank
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